BRCA1

Across TCGA patient cohorts, BRCA1 protein abundance is significantly associated with the RNA expression of many other genes, with 14,123 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible BRCA1-associated genes across cancer lineages are TMEM97, CCNA2, and AURKB. Each is linked with BRCA1 in more than 4 cancer types. Because this analysis shows association rather than direction, both BRCA1-to-partner and partner-to-BRCA1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, BRCA1 versus TMEM97 in HNSC, with a Pearson correlation of 0.58.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BRCA1→partner) and Y-score (partner→BRCA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	TMEM97 →	+1.178	+0.376	<.001	<.001	3	5
LUAD	CCNA2 →	+1.002	+0.730	<.001	<.001	3	5
LUAD	AURKB →	+1.244	+0.765	<.001	<.001	3	5
LUAD	GINS1 →	+1.183	+0.671	<.001	<.001	3	4
LUAD	MYBL2 →	+1.665	+0.783	<.001	<.001	3	4
LUAD	MCM4 →	+1.008	+0.730	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,123 associations by consensus.

BRCA1 vs TMEM97 — HNSC

Explore this scatter interactively →