BRCA1

Across TCGA patient cohorts, BRCA1 mutation is significantly associated with the total protein of many other genes, with 58 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BRCA1-associated genes across cancer lineages are ASNS, eIF4E, and Cyclin-B1. Each is linked with BRCA1 in more than 4 cancer types. Because this analysis shows association rather than direction, both BRCA1-to-partner and partner-to-BRCA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by BRCA1-low versus BRCA1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BRCA1→partner) and Y-score (partner→BRCA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	ASNS →	+0.930	+2.815	<.001	.036	3	5
UCEC	eIF4E →	+0.146	+1.584	.027	.005	3	4
COAD	Cyclin-B1 →	+0.704	+2.815	.018	.036	1	5
COAD	GAPDH →	+0.678	+2.815	.014	.036	3	3
UCEC	eEF2 →	+0.236	+1.700	.036	.040	3	3
SKCM	Notch1 →	+0.216	+2.321	.024	.035	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 58 associations by consensus.

ASNS by BRCA1 expression — COAD

Explore this box plot interactively →