BRCA1

Across TCGA cell cohorts, BRCA1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,535 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible BRCA1-associated GO terms across cancer lineages are Centrosome cycle, Double-strand break repair via homologous recombination, and Recombinational repair. Each is linked with BRCA1 in more than 19 cancer types. Because this analysis shows association rather than direction, both BRCA1-to-partner and partner-to-BRCA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Centrosome cycle grouped by BRCA1-low versus BRCA1-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (BRCA1→partner) and Y-score (partner→BRCA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Centrosome cycle →	+0.097	+1.081	.002	<.001	3	20
OESOPHAGUS	Double-strand break repair via homologous recombination →	+0.105	+1.074	<.001	.001	3	20
OESOPHAGUS	Recombinational repair →	+0.106	+1.036	.001	.001	3	20
OESOPHAGUS	DNA replication →	+0.127	+0.981	.001	.002	3	20
OESOPHAGUS	Double-strand break repair →	+0.087	+1.051	.001	<.001	3	20
BONE	DNA recombination →	+0.097	+1.089	<.001	.003	3	20

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,535 associations by consensus.

Centrosome cycle by BRCA1 expression — OESOPHAGUS

Explore this box plot interactively →