BRCA1

Across TCGA cell cohorts, BRCA1 mutation is significantly associated with the RNA expression of many other genes, with 162 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible BRCA1-associated genes across cancer lineages are SHCBP1L, DCDC2C, and SLC17A2. Each is linked with BRCA1 in more than 1 cancer types. Because this analysis shows association rather than direction, both BRCA1-to-partner and partner-to-BRCA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SHCBP1L grouped by BRCA1-low versus BRCA1-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BRCA1→partner) and Y-score (partner→BRCA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	SHCBP1L →	+0.042	+4.087	.001	.009	3	2
URINARY_TRACT	DCDC2C →	+0.135	+4.217	<.001	.005	3	2
BREAST	SLC17A2 →	+0.008	+4.196	<.001	.006	3	2
BREAST	REG3G →	+0.051	+3.672	<.001	.006	3	2
BLOOD_Leukemia	PROP1 →	+0.029	+3.289	<.001	.002	3	2
URINARY_TRACT	SEC14L3 →	+0.011	+4.217	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 162 associations by consensus.

SHCBP1L by BRCA1 expression — URINARY_TRACT

Explore this box plot interactively →