BRAT1

Across TCGA patient cohorts, BRAT1 mutation is significantly associated with the RNA expression of many other genes, with 1,618 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BRAT1-associated genes across cancer lineages are ERO1A, TAF9, and TMEM269. Each is linked with BRAT1 in more than 2 cancer types. Because this analysis shows association rather than direction, both BRAT1-to-partner and partner-to-BRAT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERO1A grouped by BRAT1-low versus BRAT1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BRAT1→partner) and Y-score (partner→BRAT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERO1A →	+0.456	+1.934	.006	.002	3	3
UCEC	TAF9 →	+0.437	+2.201	<.001	<.001	3	2
UCEC	TMEM269 →	+0.202	+2.241	<.001	<.001	3	2
UCEC	MIR6894 →	+0.347	+1.557	.003	.002	3	2
LUAD	MTCO2P23 →	+0.036	+4.612	<.001	.006	3	2
LUAD	RN7SL440P →	+0.111	+3.659	.004	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,618 associations by consensus.

ERO1A by BRAT1 expression — UCEC

Explore this box plot interactively →