BRAT1

Across TCGA patient cohorts, BRAT1 mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BRAT1-associated genes across cancer lineages are MEK1, p62 Lck ligand, and Caspase-7-cleavedD198. Each is linked with BRAT1 in more than 1 cancer types. Because this analysis shows association rather than direction, both BRAT1-to-partner and partner-to-BRAT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by BRAT1-low versus BRAT1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BRAT1→partner) and Y-score (partner→BRAT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.396	+2.321	<.001	<.001	3	2
UCEC	p62 Lck ligand →	+0.376	+2.415	<.001	.002	3	2
UCEC	Caspase-7-cleavedD198 →	+0.533	+1.807	.004	.024	3	2
UCEC	14-3-3_beta →	-0.071	-1.558	.027	.032	3	1
UCEC	eIF4E →	+0.173	+2.584	.010	.001	3	1
UCEC	A-Raf_pS299 →	-0.131	-1.502	<.001	.027	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

MEK1 by BRAT1 expression — UCEC

Explore this box plot interactively →