BRAT1

Across TCGA cell cohorts, BRAT1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,664 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible BRAT1-associated GO terms across cancer lineages are Viral translational termination-reinitiation, Meiotic chromosome condensation, and Positive regulation of isotype switching to IgG isotypes. Each is linked with BRAT1 in more than 15 cancer types. Because this analysis shows association rather than direction, both BRAT1-to-partner and partner-to-BRAT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Viral translational termination-reinitiation grouped by BRAT1-low versus BRAT1-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (BRAT1→partner) and Y-score (partner→BRAT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Viral translational termination-reinitiation →	+0.111	+1.492	<.001	<.001	3	16
UPPER_AERODIGESTIVE_TRACT	Meiotic chromosome condensation →	+0.176	+0.968	.005	.009	3	14
BLOOD_Myeloma	Positive regulation of isotype switching to IgG isotypes →	+0.164	+1.252	<.001	<.001	3	14
BONE	Pre-mRNA catabolic process →	+0.214	+0.978	<.001	<.001	3	14
BONE	Mitotic chromosome condensation →	+0.227	+1.517	<.001	<.001	3	14
LARGE_INTESTINE	Nuclear export →	+0.097	+1.233	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,664 associations by consensus.

Viral translational termination-reinitiation by BRAT1 expression — BONE

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