BRAT1

Across TCGA cell cohorts, BRAT1 mutation is significantly associated with the RNA expression of many other genes, with 262 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible BRAT1-associated genes across cancer lineages are MAGEB18, OR10J3, and C9orf92. Each is linked with BRAT1 in more than 1 cancer types. Because this analysis shows association rather than direction, both BRAT1-to-partner and partner-to-BRAT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MAGEB18 grouped by BRAT1-low versus BRAT1-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BRAT1→partner) and Y-score (partner→BRAT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	MAGEB18 →	+0.042	+4.222	.001	.007	3	1
SOFT_TISSUE	OR10J3 →	+0.016	+4.369	<.001	.008	3	1
SOFT_TISSUE	C9orf92 →	+0.144	+4.369	<.001	.008	3	1
SOFT_TISSUE	IFNA13 →	+0.030	+5.515	.004	<.001	3	1
PANCREAS	NEUROG1 →	+0.043	+5.614	<.001	.002	3	1
PANCREAS	KCNK16 →	+0.071	+5.000	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 262 associations by consensus.

MAGEB18 by BRAT1 expression — SOFT_TISSUE

Explore this box plot interactively →