BRAF

Across TCGA pan-cancer cohorts, BRAF mass-spec protein differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of BRAF’s most consistent transcriptional readouts.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where BRAF mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types BRAF is over-expressed in tumor, although a few such as HNSC and LUAD show the opposite, repressed pattern.

CCRCC, HNSC, and LUAD are the cancer types where BRAF tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in BRAF mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CCRCC	All	All	+0.140	<.001	8	view →
HNSC	Male	II,III,IV	−0.143	.004	4	view →
LUAD	Male	All	−0.118	.010	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

BRAF–CCRCC

Open the CCRCC breakdown →