BRAF

Across TCGA patient cohorts, BRAF RNA expression is significantly associated with the protein abundance of many other proteins, with 17,757 significant associations in total. GBM shows the largest number of these associations.

The most reproducible BRAF-associated proteins across cancer lineages are RRBP1, RSBN1L, and NRBF2. Each is linked with BRAF in more than 5 cancer types. Because this analysis shows association rather than direction, both BRAF-to-partner and partner-to-BRAF results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, BRAF versus RRBP1 in CCRCC, with a Pearson correlation of -0.41.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (BRAF→partner) and Y-score (partner→BRAF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	RRBP1 →	-0.336	-0.316	.006	.003	3	6
LUAD	RSBN1L →	+0.252	+0.553	<.001	<.001	3	6
CCRCC	NRBF2 →	-0.402	-0.443	.002	<.001	3	6
HNSC	PYCARD →	-0.416	-0.561	.001	.001	3	5
LSCC	TRIM24 →	+0.481	+0.610	<.001	<.001	3	5
HNSC	TRRAP →	+0.238	+0.637	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 17,757 associations by consensus.

BRAF vs RRBP1 — CCRCC

Explore this scatter interactively →