BRAF

Across TCGA patient cohorts, BRAF protein abundance is significantly associated with the RNA expression of many other genes, with 6,934 significant associations in total. GBM shows the largest number of these associations.

The most reproducible BRAF-associated genes across cancer lineages are NDUFB2, GALNT11, and CAPZA2. Each is linked with BRAF in more than 4 cancer types. Because this analysis shows association rather than direction, both BRAF-to-partner and partner-to-BRAF results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, BRAF versus NDUFB2 in OV, with a Pearson correlation of 0.40.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BRAF→partner) and Y-score (partner→BRAF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	NDUFB2 →	+0.431	+0.286	<.001	<.001	3	5
CCRCC	GALNT11 →	+0.756	+0.183	<.001	<.001	3	5
OV	CAPZA2 →	+0.472	+0.277	.001	.005	3	4
OV	PAXIP1-DT →	+0.619	+0.342	.002	.001	3	4
OV	MRPS33 →	+0.577	+0.319	<.001	<.001	3	4
LSCC	TPI1P2 →	+0.549	+0.192	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,934 associations by consensus.

BRAF vs NDUFB2 — OV

Explore this scatter interactively →