BRAF

Across TCGA patient cohorts, BRAF mutation is significantly associated with the total protein of many other genes, with 124 significant associations in total. THCA shows the largest number of these associations.

The most reproducible BRAF-associated genes across cancer lineages are ASNS, Caspase-7-cleavedD198, and IGFBP2. Each is linked with BRAF in more than 3 cancer types. Because this analysis shows association rather than direction, both BRAF-to-partner and partner-to-BRAF results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by BRAF-low versus BRAF-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BRAF→partner) and Y-score (partner→BRAF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.550	+1.906	<.001	.016	3	4
COAD	Caspase-7-cleavedD198 →	+1.233	+1.593	<.001	<.001	3	4
BLCA	IGFBP2 →	+0.424	+3.000	.034	.036	3	3
SKCM	MAPK_pT202_Y204 →	-0.372	-1.292	<.001	<.001	3	3
SKCM	Akt_pS473 →	+0.269	+0.519	.007	.021	3	3
COAD	PDCD4 →	-0.336	-1.757	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 124 associations by consensus.

ASNS by BRAF expression — UCEC

Explore this box plot interactively →