BRAF

Across TCGA cell cohorts, BRAF RNA expression is significantly associated with the go_rna of many other GO terms, with 4,714 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible BRAF-associated GO terms across cancer lineages are Positive regulation of mRNA metabolic process, Pre-miRNA processing, and Regulation of nucleotide-excision repair. Each is linked with BRAF in more than 15 cancer types. Because this analysis shows association rather than direction, both BRAF-to-partner and partner-to-BRAF results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of mRNA metabolic process grouped by BRAF-low versus BRAF-high in BLOOD_Lymphoma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (BRAF→partner) and Y-score (partner→BRAF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	Positive regulation of mRNA metabolic process →	+0.059	+0.618	<.001	.001	3	16
STOMACH	Pre-miRNA processing →	+0.122	+0.971	<.001	<.001	3	16
BLOOD_Leukemia	Regulation of nucleotide-excision repair →	+0.104	+0.753	<.001	<.001	3	15
LUNG_SCLC	Protein polyubiquitination →	+0.036	+0.486	.007	.003	2	15
LUNG_SCLC	Epigenetic regulation of gene expression →	+0.079	+0.590	<.001	<.001	3	14
SOFT_TISSUE	Nucleic acid transport →	+0.093	+0.740	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,714 associations by consensus.

Positive regulation of mRNA metabolic process by BRAF expression — BLOOD_Lymphoma

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