BPTF

Across TCGA patient cohorts, BPTF mutation is significantly associated with the total protein of many other genes, with 77 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BPTF-associated genes across cancer lineages are INPP4B, MEK1, and PCNA. Each is linked with BPTF in more than 2 cancer types. Because this analysis shows association rather than direction, both BPTF-to-partner and partner-to-BPTF results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, INPP4B grouped by BPTF-low versus BPTF-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BPTF→partner) and Y-score (partner→BPTF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	INPP4B →	-0.189	-1.167	.024	.005	3	3
UCEC	MEK1 →	+0.357	+1.788	<.001	<.001	3	3
UCEC	PCNA →	+0.205	+1.469	<.001	<.001	3	3
COAD	ATM →	-0.532	-2.691	<.001	.006	3	3
UCEC	4E-BP1 →	+0.250	+1.736	<.001	.005	3	3
STAD	Chk2 →	+0.389	+2.584	.002	.010	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 77 associations by consensus.

INPP4B by BPTF expression — UCEC

Explore this box plot interactively →