BPTF

Across TCGA cell cohorts, BPTF mutation is significantly associated with the RNA expression of many other genes, with 671 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible BPTF-associated genes across cancer lineages are ACTR6, VPS29, and GLE1. Each is linked with BPTF in more than 2 cancer types. Because this analysis shows association rather than direction, both BPTF-to-partner and partner-to-BPTF results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACTR6 grouped by BPTF-low versus BPTF-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BPTF→partner) and Y-score (partner→BPTF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ACTR6 →	+0.651	+2.036	<.001	.002	3	3
CNS	VPS29 →	+0.428	+3.220	.008	.005	3	2
CNS	GLE1 →	+0.397	+3.237	.003	.003	3	2
CNS	GOLGA1 →	+0.405	+3.144	.007	.007	3	2
CNS	PI4K2A →	+0.526	+3.722	<.001	<.001	3	2
CNS	JMJD1C →	+0.533	+3.321	.002	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 671 associations by consensus.

ACTR6 by BPTF expression — LARGE_INTESTINE

Explore this box plot interactively →