BPNT2

Across TCGA patient cohorts, BPNT2 mutation is significantly associated with the total protein of many other genes, with 42 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BPNT2-associated genes across cancer lineages are PCNA, PDCD4, and Src_pY416. Each is linked with BPNT2 in more than 1 cancer types. Because this analysis shows association rather than direction, both BPNT2-to-partner and partner-to-BPNT2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by BPNT2-low versus BPNT2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BPNT2→partner) and Y-score (partner→BPNT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.218	+2.321	.010	.033	3	2
UCEC	PDCD4 →	-0.555	-2.000	.002	.010	3	2
UCEC	Src_pY416 →	-0.205	-1.986	.030	.010	3	2
UCEC	C-Raf →	+0.233	+2.906	<.001	.001	3	2
UCEC	Cyclin-E2 →	+0.179	+2.009	.006	.017	3	2
UCEC	14-3-3_beta →	-0.080	-2.973	.042	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

PCNA by BPNT2 expression — UCEC

Explore this box plot interactively →