BPNT1

Across TCGA patient cohorts, BPNT1 mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BPNT1-associated genes across cancer lineages are eIF4G, ERK2, and GAPDH. Each is linked with BPNT1 in more than 1 cancer types. Because this analysis shows association rather than direction, both BPNT1-to-partner and partner-to-BPNT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4G grouped by BPNT1-low versus BPNT1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BPNT1→partner) and Y-score (partner→BPNT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4G →	+0.277	+1.700	.035	.044	3	1
UCEC	ERK2 →	+0.181	+2.999	.027	.035	3	1
UCEC	GAPDH →	+0.659	+3.459	.003	.005	3	1
UCEC	JNK2 →	+0.260	+2.196	.002	.032	3	1
UCEC	Ku80 →	+0.247	+2.235	.013	.006	3	1
UCEC	MEK1 →	+0.491	+3.584	.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

eIF4G by BPNT1 expression — UCEC

Explore this box plot interactively →