BPIFB4

mutation — cross-omics
Cross-omicsMUTATION → PROTEIN-RPPAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, BPIFB4 mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BPIFB4-associated genes across cancer lineages are Caspase-8, Gab2, and p27_pT157. Each is linked with BPIFB4 in more than 1 cancer types. Because this analysis shows association rather than direction, both BPIFB4-to-partner and partner-to-BPIFB4 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BPIFB4→partner) and Y-score (partner→BPIFB4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
UCECCaspase-8 →-0.257-3.060.002<.00132
UCECGab2 →+0.280+1.247.021.04532
UCECp27_pT157 →-0.044-1.514.025.01532
UCECPCNA →+0.188+1.906.010.01532
UCECCaspase-7-cleavedD198 →+0.752+3.107<.001<.00132
LUSCMYH11 →-1.047-3.312.018.01031
Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

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