BPIFB2

Across TCGA cell cohorts, BPIFB2 mutation is significantly associated with the RNA expression of many other genes, with 11 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible BPIFB2-associated genes across cancer lineages are TAS2R60, NEU2, and CCDC70. Each is linked with BPIFB2 in more than 1 cancer types. Because this analysis shows association rather than direction, both BPIFB2-to-partner and partner-to-BPIFB2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TAS2R60 grouped by BPIFB2-low versus BPIFB2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BPIFB2→partner) and Y-score (partner→BPIFB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TAS2R60 →	+0.023	+3.347	<.001	.005	3	2
LUNG_SCLC	NEU2 →	+0.012	+4.058	<.001	.007	3	1
LUNG_SCLC	CCDC70 →	+0.050	+4.256	.001	.002	3	1
LUNG_SCLC	HMHB1 →	+0.840	+3.817	<.001	.004	3	1
LUNG_SCLC	SMCP →	+0.038	+4.058	<.001	.007	3	1
LUNG_SCLC	IFNL3 →	+0.053	+3.817	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

TAS2R60 by BPIFB2 expression — LARGE_INTESTINE

Explore this box plot interactively →