BPIFA2

Across TCGA patient cohorts, BPIFA2 mutation is significantly associated with the RNA expression of many other genes, with 786 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible BPIFA2-associated genes across cancer lineages are MRNIP, ERCC3, and ZNF274. Each is linked with BPIFA2 in more than 1 cancer types. Because this analysis shows association rather than direction, both BPIFA2-to-partner and partner-to-BPIFA2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MRNIP grouped by BPIFA2-low versus BPIFA2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BPIFA2→partner) and Y-score (partner→BPIFA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MRNIP →	+0.483	+3.470	.003	.003	3	2
UCEC	ERCC3 →	+0.436	+3.470	.008	.003	3	2
UCEC	ZNF274 →	+0.527	+3.338	.006	.005	3	2
SKCM	ITGAE →	+0.596	+3.208	.001	.009	3	2
SKCM	CCDC93 →	+0.737	+3.629	<.001	.001	3	2
UCEC	PSMC3IP →	+1.038	+3.345	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 786 associations by consensus.

MRNIP by BPIFA2 expression — UCEC

Explore this box plot interactively →