BPIFA2

Across TCGA patient cohorts, BPIFA2 mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BPIFA2-associated genes across cancer lineages are Caspase-8, FoxM1, and INPP4B. Each is linked with BPIFA2 in more than 1 cancer types. Because this analysis shows association rather than direction, both BPIFA2-to-partner and partner-to-BPIFA2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-8 grouped by BPIFA2-low versus BPIFA2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BPIFA2→partner) and Y-score (partner→BPIFA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-8 →	-0.323	-3.000	.026	.036	2	2
UCEC	FoxM1 →	+0.389	+2.817	.009	.036	2	1
UCEC	INPP4B →	-0.444	-2.986	.017	.037	2	1
UCEC	mTOR_pS2448 →	-0.242	-3.000	.005	.037	2	1
UCEC	p38-MAPK_pT180_Y182 →	-0.569	-2.986	.028	.037	2	1
UCEC	MEK1 →	+0.648	+3.000	.002	.037	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

Caspase-8 by BPIFA2 expression — UCEC

Explore this box plot interactively →