BPI

Across TCGA patient cohorts, BPI mutation is significantly associated with the RNA expression of many other genes, with 1,489 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BPI-associated genes across cancer lineages are E2F6P1, RPS17P7, and RPL12P43. Each is linked with BPI in more than 2 cancer types. Because this analysis shows association rather than direction, both BPI-to-partner and partner-to-BPI results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, E2F6P1 grouped by BPI-low versus BPI-high in READ.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BPI→partner) and Y-score (partner→BPI) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
READ	E2F6P1 →	+0.058	+4.257	<.001	.007	3	3
HNSC	RPS17P7 →	+0.148	+3.988	.007	.005	3	2
HNSC	RPL12P43 →	+0.071	+4.498	.001	.002	3	2
HNSC	FABP5P6 →	+0.150	+4.321	.002	.003	3	2
HNSC	RNU6-693P →	+0.203	+4.883	<.001	.004	3	2
UCEC	RPL23AP82 →	+0.389	+3.480	.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,489 associations by consensus.

E2F6P1 by BPI expression — READ

Explore this box plot interactively →