BPI

Across TCGA cell cohorts, BPI RNA expression is significantly associated with the go_rna of many other GO terms, with 1,690 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible BPI-associated GO terms across cancer lineages are Myotube cell development, Regulation of transmembrane receptor protein serine/threonine kinase signaling pathway, and Cell-substrate adhesion. Each is linked with BPI in more than 4 cancer types. Because this analysis shows association rather than direction, both BPI-to-partner and partner-to-BPI results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Myotube cell development grouped by BPI-low versus BPI-high in BLOOD_Leukemia.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (BPI→partner) and Y-score (partner→BPI) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	Myotube cell development →	+0.081	+1.790	<.001	<.001	3	5
SKIN	Regulation of transmembrane receptor protein serine/threonine kinase signaling pathway →	+0.037	+0.280	<.001	.006	3	4
BLOOD_Leukemia	Cell-substrate adhesion →	+0.062	+1.717	<.001	.002	3	4
BLOOD_Leukemia	Serotonin uptake →	-0.729	-1.384	<.001	.009	3	4
BLOOD_Leukemia	Negative regulation of biomineral tissue development →	+0.095	+1.495	<.001	<.001	3	4
BLOOD_Leukemia	Response to lipoteichoic acid →	-0.104	-1.265	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,690 associations by consensus.

Myotube cell development by BPI expression — BLOOD_Leukemia

Explore this box plot interactively →