BORCS8

Across TCGA pan-cancer cohorts, BORCS8 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated BORCS8 data layer compared with 24 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher BORCS8 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated BORCS8 expression acts as an unfavorable survival marker, although some lineages such as UCEC and CCRCC show a favorable association.

UCEC, LUAD, and CCRCC are the cancer types where BORCS8 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Quartile	All	0.943	0.680	.010	20	view →
LUAD	OS	Median	III,IV	0.315	0.823	.001	14	view →
CCRCC	DFS	Tertile	IV	0.961	0.188	.024	14	view →
PDAC	OS	Quartile	All	0.654	0.432	.016	5	view →
HNSC	DFS	Tertile	II,III,IV	0.980	0.887	.028	5	view →
LSCC	OS	Tertile	II,III,IV	0.914	0.676	.047	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

BORCS8–UCEC (DFS)

Open the UCEC breakdown →