BORCS8-MEF2B

Across TCGA pan-cancer cohorts, BORCS8-MEF2B RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated BORCS8-MEF2B data layer compared with 1 for mutation status.

The strongest signal is observed in kidney chromophobe (KICH), where higher BORCS8-MEF2B RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated BORCS8-MEF2B expression acts as an unfavorable survival marker, although some lineages such as UCS and GBM show a favorable association.

KICH, ACC, and KIRC are the cancer types where BORCS8-MEF2B RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KICH	DFS	Tertile	III,IV	0.160	0.931	<.001	84	view →
ACC	DFS	Tertile	All	0.338	0.787	<.001	72	view →
KIRC	DFS	Tertile	IV	0.274	0.631	.003	55	view →
COAD	DFS	Median	All	0.705	0.848	.002	27	view →
UCS	DFS	Tertile	IV	0.875	0.239	.024	24	view →
LIHC	DFS	Tertile	All	0.472	0.632	.003	24	view →
GBM	OS	Tertile	All	0.548	0.345	.001	19	view →
HNSC	DFS	Median	IV	0.429	0.265	.001	18	view →
BLCA	OS	Median	III,IV	0.755	0.605	.003	14	view →
SKCM	OS	Quartile	II,III,IV	0.456	0.312	.009	13	view →
MESO	OS	Quartile	III,IV	0.446	0.752	.017	12	view →
CHOL	DFS	Quartile	II,III,IV	0.591	0.173	.004	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

BORCS8-MEF2B–KICH (DFS)

Open the KICH breakdown →