BORA

Across TCGA patient cohorts, BORA mutation is significantly associated with the RNA expression of many other genes, with 1,631 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BORA-associated genes across cancer lineages are RNA5SP459, ATP6V1E1P2, and MIR488. Each is linked with BORA in more than 2 cancer types. Because this analysis shows association rather than direction, both BORA-to-partner and partner-to-BORA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP459 grouped by BORA-low versus BORA-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BORA→partner) and Y-score (partner→BORA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RNA5SP459 →	+1.323	+7.816	<.001	.008	3	3
CESC	ATP6V1E1P2 →	+0.157	+5.539	<.001	.004	3	2
SKCM	MIR488 →	+0.623	+7.816	<.001	.008	3	2
SKCM	SUMO2P2 →	+0.334	+7.816	<.001	.008	3	2
BLCA	LINC02394 →	+0.249	+5.411	<.001	.005	3	2
HNSC	SRIP3 →	+0.171	+4.716	.003	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,631 associations by consensus.

RNA5SP459 by BORA expression — SKCM

Explore this box plot interactively →