BORA

Across TCGA patient cohorts, BORA mutation is significantly associated with the total protein of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BORA-associated genes across cancer lineages are FASN, FoxM1, and INPP4B. Each is linked with BORA in more than 1 cancer types. Because this analysis shows association rather than direction, both BORA-to-partner and partner-to-BORA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FASN grouped by BORA-low versus BORA-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BORA→partner) and Y-score (partner→BORA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FASN →	+0.448	+2.321	.023	.035	3	1
UCEC	FoxM1 →	+0.286	+2.321	.028	.035	3	1
UCEC	INPP4B →	-0.458	-3.446	.004	.005	3	1
UCEC	PCNA →	+0.233	+3.169	.032	.019	3	1
UCEC	Tuberin →	+0.415	+3.009	.002	.019	3	1
UCEC	4E-BP1 →	+0.417	+3.169	.002	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

FASN by BORA expression — UCEC

Explore this box plot interactively →