BORA

Across TCGA cell cohorts, BORA mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible BORA-associated genes across cancer lineages are SIGLEC7, MSGN1, and TBC1D21. Each is linked with BORA in more than 1 cancer types. Because this analysis shows association rather than direction, both BORA-to-partner and partner-to-BORA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SIGLEC7 grouped by BORA-low versus BORA-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BORA→partner) and Y-score (partner→BORA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	SIGLEC7 →	+0.063	+4.906	<.001	.006	3	1
LARGE_INTESTINE	MSGN1 →	+0.100	+3.930	<.001	.003	3	1
LARGE_INTESTINE	TBC1D21 →	+0.012	+4.437	<.001	.004	3	1
LARGE_INTESTINE	C12orf40 →	+0.009	+3.684	<.001	.006	3	1
LARGE_INTESTINE	SPRR2F →	+0.629	+3.707	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

SIGLEC7 by BORA expression — OESOPHAGUS

Explore this box plot interactively →