BOP1

Across TCGA patient cohorts, BOP1 protein abundance is significantly associated with the RNA expression of many other genes, with 21,179 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible BOP1-associated genes across cancer lineages are TOP1MT, MYBL2, and MRGBP. Each is linked with BOP1 in more than 9 cancer types. Because this analysis shows association rather than direction, both BOP1-to-partner and partner-to-BOP1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, BOP1 versus TOP1MT in UCEC, with a Pearson correlation of 0.36.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BOP1→partner) and Y-score (partner→BOP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TOP1MT →	+0.841	+0.263	<.001	<.001	3	10
UCEC	MYBL2 →	+1.696	+0.333	<.001	<.001	3	9
UCEC	MRGBP →	+0.879	+0.223	<.001	.001	3	9
HNSC	DKC1 →	+1.053	+0.296	<.001	<.001	3	9
UCEC	EME1 →	+1.095	+0.277	<.001	<.001	3	9
HNSC	RPL8 →	+1.152	+0.261	.006	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 21,179 associations by consensus.

BOP1 vs TOP1MT — UCEC

Explore this scatter interactively →