BOLA3

Across TCGA pan-cancer cohorts, BOLA3 RNA is linked to patient survival in 30 of 34 cancer types, making it the most broadly survival-associated BOLA3 data layer compared with 1 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher BOLA3 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated BOLA3 expression acts as an unfavorable survival marker, although some lineages such as LUSC and READ show a favorable association.

ACC, UVM, and KIRC are the cancer types where BOLA3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	OS	Median	All	0.774	0.963	<.001	139	view →
UVM	DFS	Median	All	0.301	0.685	<.001	135	view →
KIRC	OS	Median	All	0.755	0.852	<.001	104	view →
LUAD	OS	Quartile	All	0.249	0.663	<.001	87	view →
SKCM	DFS	Median	All	0.531	0.739	<.001	68	view →
KICH	OS	Median	All	0.652	1.000	.001	68	view →
LIHC	OS	Median	All	0.613	0.757	<.001	63	view →
SCLC	OS	Median	All	0.330	0.633	.001	59	view →
LGG	OS	Median	All	0.705	0.911	<.001	54	view →
KIRP	DFS	Quartile	All	0.841	1.000	<.001	54	view →
UCS	DFS	Median	IV	0.367	0.952	.001	50	view →
HNSC	DFS	Quartile	All	0.289	0.480	.003	44	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 30 lineages.

BOLA3–ACC (OS)

Open the ACC breakdown →