BOLA3

Across TCGA pan-cancer cohorts, BOLA3 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated BOLA3 data layer compared with 30 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher BOLA3 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated BOLA3 expression acts as an unfavorable survival marker, although some lineages such as LUAD and GBM show a favorable association.

HNSC, CCRCC, and PDAC are the cancer types where BOLA3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Tertile	All	0.532	0.816	.003	49	view →
CCRCC	DFS	Quartile	II,III,IV	0.229	0.754	<.001	29	view →
PDAC	OS	Tertile	III,IV	0.220	0.552	.004	21	view →
LSCC	DFS	Tertile	III,IV	0.637	0.980	.023	10	view →
LUAD	DFS	Quartile	III,IV	0.955	0.432	.031	4	view →
GBM	DFS	Quartile	All	0.808	0.502	.019	3	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

BOLA3–HNSC (OS)

Open the HNSC breakdown →