BNIPL

Across TCGA patient cohorts, BNIPL mutation is significantly associated with the RNA expression of many other genes, with 1,813 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BNIPL-associated genes across cancer lineages are MT1CP, LYPLA1P1, and RNU7-29P. Each is linked with BNIPL in more than 1 cancer types. Because this analysis shows association rather than direction, both BNIPL-to-partner and partner-to-BNIPL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MT1CP grouped by BNIPL-low versus BNIPL-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BNIPL→partner) and Y-score (partner→BNIPL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MT1CP →	+0.172	+2.064	.001	.006	3	2
UCEC	LYPLA1P1 →	+0.048	+3.547	<.001	.002	3	2
UCEC	RNU7-29P →	+0.182	+3.219	<.001	.004	3	2
UCEC	SEPTIN14P8 →	+0.199	+2.278	<.001	.001	3	2
UCEC	ZC3H18 →	+0.449	+2.534	.001	.001	3	2
UCEC	AARS1 →	+0.529	+2.032	.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,813 associations by consensus.

MT1CP by BNIPL expression — UCEC

Explore this box plot interactively →