BNIP3P25

Across TCGA pan-cancer cohorts, BNIP3P25 RNA is linked to patient survival in 17 of 34 cancer types, making it the most broadly survival-associated BNIP3P25 data layer.

The strongest signal is observed in rectum adenocarcinoma (READ), where higher BNIP3P25 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated BNIP3P25 expression acts as an unfavorable survival marker, although some lineages such as LUAD and KICH show a favorable association.

READ, LUAD, and KICH are the cancer types where BNIP3P25 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
READ	DFS	Tertile	III,IV	0.426	0.814	<.001	57	view →
LUAD	DFS	Median	All	0.422	0.283	<.001	39	view →
KICH	OS	Median	III,IV	0.957	0.367	<.001	37	view →
MESO	OS	Tertile	All	0.246	0.470	<.001	36	view →
UVM	DFS	Quartile	II,III,IV	0.345	0.655	.007	34	view →
BLCA	DFS	Median	All	0.591	0.458	.010	25	view →
KIRC	OS	Median	II,III,IV	0.413	0.655	.001	24	view →
STAD	OS	Tertile	III,IV	0.678	0.340	.004	24	view →
SKCM	DFS	Tertile	II,III,IV	0.576	0.759	.003	18	view →
COAD	OS	Tertile	All	0.816	0.885	.013	15	view →
LAML	DFS	Quartile	All	0.536	0.285	.014	14	view →
ESCA	OS	Tertile	IV	0.373	0.916	.024	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 17 lineages.

BNIP3P25–READ (DFS)

Open the READ breakdown →