BNIP3

Across TCGA pan-cancer cohorts, BNIP3 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated BNIP3 data layer compared with 27 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher BNIP3 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated BNIP3 expression acts as an unfavorable survival marker, although some lineages such as HNSC and UCEC show a favorable association.

HNSC, PDAC, and UCEC are the cancer types where BNIP3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Quartile	All	1.000	0.550	<.001	64	view →
PDAC	DFS	Median	All	0.323	0.614	.002	18	view →
UCEC	DFS	Median	II,III,IV	0.870	0.531	.041	4	view →
CCRCC	OS	Quartile	All	0.710	0.952	.016	4	view →
LUAD	OS	Median	II,III,IV	0.328	0.804	.014	2	view →
LSCC	DFS	Quartile	All	0.495	1.000	.040	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

BNIP3–HNSC (OS)

Open the HNSC breakdown →