BNIP3

Across TCGA patient cohorts, BNIP3 mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BNIP3-associated genes across cancer lineages are Acetyl-a-Tubulin-Lys40, Notch1, and STAT3_pY705. Each is linked with BNIP3 in more than 1 cancer types. Because this analysis shows association rather than direction, both BNIP3-to-partner and partner-to-BNIP3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Acetyl-a-Tubulin-Lys40 grouped by BNIP3-low versus BNIP3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BNIP3→partner) and Y-score (partner→BNIP3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.522	+2.179	.033	.034	3	1
UCEC	Notch1 →	+0.173	+2.820	.011	.035	3	1
UCEC	STAT3_pY705 →	-0.496	-2.459	<.001	.020	3	1
UCEC	VHL →	-1.128	-2.459	<.001	.019	3	1
UCEC	4E-BP1_pT37_T46 →	-0.472	-2.986	.009	.035	3	1
UCEC	MEK1 →	+0.504	+3.169	.004	.019	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

Acetyl-a-Tubulin-Lys40 by BNIP3 expression — UCEC

Explore this box plot interactively →