BNIP3

Across TCGA cell cohorts, BNIP3 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,197 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible BNIP3-associated GO terms across cancer lineages are Negative regulation of mitochondrial membrane permeability involved in apoptotic process, Negative regulation of mitochondrial fusion, and Mitochondrial fragmentation involved in apoptotic process. Each is linked with BNIP3 in more than 15 cancer types. Because this analysis shows association rather than direction, both BNIP3-to-partner and partner-to-BNIP3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of mitochondrial membrane permeability involved in apoptotic process grouped by BNIP3-low versus BNIP3-high in KIDNEY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (BNIP3→partner) and Y-score (partner→BNIP3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	Negative regulation of mitochondrial membrane permeability involved in apoptotic process →	+0.264	+1.603	.002	.002	3	16
LUNG_SCLC	Negative regulation of mitochondrial fusion →	+0.170	+1.476	<.001	<.001	3	15
OVARY	Mitochondrial fragmentation involved in apoptotic process →	+0.193	+1.866	<.001	<.001	3	13
OVARY	Mitochondrial protein catabolic process →	+0.193	+2.175	<.001	<.001	3	13
SKIN	Purine nucleoside diphosphate catabolic process →	+0.145	+1.606	<.001	<.001	3	13
SKIN	Purine ribonucleoside diphosphate catabolic process →	+0.145	+1.606	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,197 associations by consensus.

Negative regulation of mitochondrial membrane permeability involved in apoptotic process by BNIP3 expression — KIDNEY

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