BNIP2

Across TCGA pan-cancer cohorts, BNIP2 mass-spec protein is linked to patient survival in 8 of 34 cancer types, making it a survival-associated BNIP2 data layer compared with 27 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher BNIP2 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated BNIP2 expression acts as an unfavorable survival marker, although some lineages such as HNSC show a favorable association.

COAD, LSCC, and PDAC are the cancer types where BNIP2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	II,III,IV	0.840	1.000	.014	54	view →
LSCC	DFS	Quartile	II,III,IV	0.383	0.872	.003	20	view →
PDAC	OS	Median	III,IV	0.471	1.000	.003	19	view →
CCRCC	DFS	Median	All	0.476	0.973	.001	16	view →
HNSC	OS	Quartile	III,IV	0.746	0.500	.022	10	view →
LUAD	OS	Median	III,IV	0.231	0.602	.027	4	view →
UCEC	DFS	Tertile	II,III,IV	0.517	0.901	.025	4	view →
GBM	DFS	Tertile	All	0.225	0.417	.010	4	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

BNIP2–COAD (DFS)

Open the COAD breakdown →