BNIP2

Across TCGA patient cohorts, BNIP2 mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BNIP2-associated genes across cancer lineages are IGFBP2, Lck, and C-Raf. Each is linked with BNIP2 in more than 1 cancer types. Because this analysis shows association rather than direction, both BNIP2-to-partner and partner-to-BNIP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IGFBP2 grouped by BNIP2-low versus BNIP2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BNIP2→partner) and Y-score (partner→BNIP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	IGFBP2 →	-1.133	-3.169	.001	.020	3	1
UCEC	Lck →	+0.341	+3.169	.001	.020	3	1
UCEC	C-Raf →	+0.233	+3.000	.003	.036	3	1
UCEC	EGFR_pY1068 →	-0.356	-3.169	.009	.020	2	1
UCEC	A-Raf_pS299 →	-0.159	-3.169	.015	.020	1	1
UCEC	PI3K-p85 →	+0.290	+3.169	.011	.020	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

IGFBP2 by BNIP2 expression — UCEC

Explore this box plot interactively →