BNIP2

Across TCGA cell cohorts, BNIP2 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,938 significant associations in total. BONE shows the largest number of these associations.

The most reproducible BNIP2-associated GO terms across cancer lineages are Protein targeting to vacuole, Establishment of protein localization to vacuole, and Cytosolic transport. Each is linked with BNIP2 in more than 14 cancer types. Because this analysis shows association rather than direction, both BNIP2-to-partner and partner-to-BNIP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Protein targeting to vacuole grouped by BNIP2-low versus BNIP2-high in CNS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (BNIP2→partner) and Y-score (partner→BNIP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	Protein targeting to vacuole →	+0.075	+0.672	<.001	<.001	3	15
PANCREAS	Establishment of protein localization to vacuole →	+0.063	+0.940	<.001	<.001	3	15
SKIN	Cytosolic transport →	+0.058	+0.567	.002	<.001	3	15
SOFT_TISSUE	Endosomal transport →	+0.060	+0.892	<.001	<.001	3	14
BONE	Endocytic recycling →	+0.078	+0.554	<.001	.001	3	13
CNS	Lysosomal transport →	+0.047	+0.677	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,938 associations by consensus.

Protein targeting to vacuole by BNIP2 expression — CNS

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