BNIP2

Across TCGA cell cohorts, BNIP2 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible BNIP2-associated genes across cancer lineages are SPATA31A5, BPIFB6, and OR10W1. Each is linked with BNIP2 in more than 1 cancer types. Because this analysis shows association rather than direction, both BNIP2-to-partner and partner-to-BNIP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SPATA31A5 grouped by BNIP2-low versus BNIP2-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BNIP2→partner) and Y-score (partner→BNIP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	SPATA31A5 →	+0.013	+5.662	<.001	.002	3	1
LARGE_INTESTINE	BPIFB6 →	+0.025	+5.022	<.001	.002	3	1
LARGE_INTESTINE	OR10W1 →	+0.024	+5.562	<.001	<.001	3	1
LARGE_INTESTINE	BTNL2 →	+0.081	+4.415	<.001	.007	3	1
LARGE_INTESTINE	INSRR →	+0.047	+4.584	<.001	.003	1	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

SPATA31A5 by BNIP2 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →