BNIP1

Across TCGA pan-cancer cohorts, BNIP1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated BNIP1 data layer compared with 24 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher BNIP1 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated BNIP1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and COAD show a favorable association.

HNSC, COAD, and LSCC are the cancer types where BNIP1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Tertile	All	0.882	0.597	<.001	49	view →
COAD	DFS	Median	III,IV	1.000	0.875	.028	12	view →
LSCC	OS	Quartile	All	0.686	0.939	.012	5	view →
CCRCC	OS	Median	All	0.741	1.000	.027	4	view →
GBM	DFS	Quartile	All	0.902	0.741	.016	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

BNIP1–HNSC (OS)

Open the HNSC breakdown →