BNC2

Across TCGA pan-cancer cohorts, BNC2 Mutation is linked to patient survival in 12 of 34 cancer types, making it a survival-associated BNC2 data layer compared with 22 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in thymoma (THYM), where higher BNC2 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated BNC2 expression acts as an unfavorable survival marker, although some lineages such as UCEC and BLCA show a favorable association.

THYM, UCEC, and SKCM are the cancer types where BNC2 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THYM	OS	Median	III,IV	0.103	0.944	<.001	42	view →
UCEC	DFS	Median	All	0.797	0.625	.001	36	view →
SKCM	DFS	Median	All	0.386	0.629	.001	17	view →
SCLC	OS	Median	All	0.210	0.592	.003	12	view →
BLCA	DFS	Median	III,IV	1.000	0.295	.015	9	view →
LUSC	OS	Median	II,III,IV	0.156	0.687	<.001	8	view →
UCS	OS	Median	All	0.185	0.686	.034	6	view →
OV	DFS	Median	All	0.243	0.542	.005	6	view →
SARC	OS	Median	All	0.302	0.733	.013	6	view →
LGG	DFS	Median	All	0.236	0.731	.001	6	view →
PRAD	DFS	Median	All	0.067	0.775	<.001	6	view →
LUAD	OS	Median	II,III,IV	1.000	0.508	.035	2	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 12 lineages.

BNC2–THYM (OS)

Open the THYM breakdown →