BMX

Across TCGA cell cohorts, BMX mutation is significantly associated with the RNA expression of many other genes, with 12 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible BMX-associated genes across cancer lineages are SPPL2C, C8B, and DRD3. Each is linked with BMX in more than 1 cancer types. Because this analysis shows association rather than direction, both BMX-to-partner and partner-to-BMX results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SPPL2C grouped by BMX-low versus BMX-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BMX→partner) and Y-score (partner→BMX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	SPPL2C →	+0.012	+4.922	<.001	.009	3	2
SKIN	C8B →	+0.098	+4.467	<.001	.004	3	1
BLOOD_Leukemia	DRD3 →	+0.019	+5.201	<.001	.006	3	1
BLOOD_Leukemia	NKX2-6 →	+0.591	+5.201	<.001	.006	3	1
BLOOD_Leukemia	HTR3D →	+0.019	+5.539	<.001	.003	3	1
BLOOD_Leukemia	RBMY1D →	+0.180	+5.539	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

SPPL2C by BMX expression — BLOOD_Leukemia

Explore this box plot interactively →