BMT2

Across TCGA patient cohorts, BMT2 mutation is significantly associated with the total protein of many other genes, with 49 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BMT2-associated genes across cancer lineages are FOXO3a_pS318_S321, p38-MAPK_pT180_Y182, and FASN. Each is linked with BMT2 in more than 2 cancer types. Because this analysis shows association rather than direction, both BMT2-to-partner and partner-to-BMT2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FOXO3a_pS318_S321 grouped by BMT2-low versus BMT2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BMT2→partner) and Y-score (partner→BMT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FOXO3a_pS318_S321 →	-0.123	-2.797	.001	<.001	3	3
UCEC	p38-MAPK_pT180_Y182 →	-0.364	-1.934	.008	<.001	3	3
UCEC	FASN →	+0.312	+1.415	.009	.043	3	2
UCEC	FoxM1 →	+0.212	+1.857	.007	.004	3	2
UCEC	HER2_pY1248 →	-0.170	-2.222	.038	<.001	3	2
UCEC	Ku80 →	+0.196	+1.276	.006	.012	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 49 associations by consensus.

FOXO3a_pS318_S321 by BMT2 expression — UCEC

Explore this box plot interactively →