BMS1

Across TCGA patient cohorts, BMS1 mutation is significantly associated with the total protein of many other genes, with 60 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BMS1-associated genes across cancer lineages are ATM, JNK_pT183_Y185, and JNK2. Each is linked with BMS1 in more than 3 cancer types. Because this analysis shows association rather than direction, both BMS1-to-partner and partner-to-BMS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by BMS1-low versus BMS1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BMS1→partner) and Y-score (partner→BMS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.546	-1.700	<.001	.001	3	4
UCEC	JNK_pT183_Y185 →	-0.124	-1.415	.016	.043	3	3
UCEC	JNK2 →	+0.208	+2.348	<.001	.002	3	3
UCEC	Ku80 →	+0.159	+1.487	.028	.004	3	3
UCEC	TFRC →	+0.327	+3.584	.044	.002	3	3
UCEC	Caspase-8 →	-0.235	-3.060	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 60 associations by consensus.

ATM by BMS1 expression — UCEC

Explore this box plot interactively →