BMPR2

mutation — cross-omics
Cross-omicsMUTATION → PROTEIN-RPPAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, BMPR2 mutation is significantly associated with the total protein of many other genes, with 77 significant associations in total. COAD shows the largest number of these associations.

The most reproducible BMPR2-associated genes across cancer lineages are Heregulin, PDK1_pS241, and EGFR_pY1068. Each is linked with BMPR2 in more than 2 cancer types. Because this analysis shows association rather than direction, both BMPR2-to-partner and partner-to-BMPR2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BMPR2→partner) and Y-score (partner→BMPR2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
COADHeregulin →+0.186+3.000.001.03433
COADPDK1_pS241 →-0.161-2.102.009.01733
COADEGFR_pY1068 →-0.262-2.309.031.03332
COADeIF4E →+0.197+1.749.002.04932
UCECA-Raf_pS299 →-0.125-2.502.001.00132
UCECERK2 →+0.146+1.700.017.04032
Each partner links to its Q-omics profile. Showing the 6 strongest of 77 associations by consensus.

Exploration