BMP7

Across TCGA pan-cancer cohorts, BMP7 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated BMP7 data layer compared with 20 for mass-spec protein and 1 for mass-spec protein.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where higher BMP7 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated BMP7 expression acts as an unfavorable survival marker, although some lineages such as UCEC and SKCM show a favorable association.

LIHC, UCEC, and KICH are the cancer types where BMP7 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LIHC	OS	Median	All	0.093	0.783	<.001	30	view →
UCEC	DFS	Median	All	0.870	0.619	.004	20	view →
KICH	DFS	Median	All	0.102	0.848	.004	13	view →
SKCM	DFS	Median	III,IV	1.000	0.567	.008	13	view →
ACC	OS	Median	All	0.177	0.632	.021	7	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

BMP7–LIHC (OS)

Open the LIHC breakdown →