BMP7

Across TCGA patient cohorts, BMP7 mutation is significantly associated with the RNA expression of many other genes, with 2,529 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BMP7-associated genes across cancer lineages are YARS1, H2AZ1, and FEN1. Each is linked with BMP7 in more than 3 cancer types. Because this analysis shows association rather than direction, both BMP7-to-partner and partner-to-BMP7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, YARS1 grouped by BMP7-low versus BMP7-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BMP7→partner) and Y-score (partner→BMP7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	YARS1 →	+0.419	+1.401	<.001	.004	3	4
UCEC	H2AZ1 →	+0.454	+2.087	.001	.005	3	3
UCEC	FEN1 →	+0.454	+1.380	.003	.004	3	3
UCEC	SHCBP1 →	+0.519	+2.425	<.001	.001	3	3
UCEC	SPATA5L1 →	+0.378	+1.724	<.001	.003	3	3
UCEC	RAD51 →	+0.566	+1.358	<.001	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,529 associations by consensus.

YARS1 by BMP7 expression — UCEC

Explore this box plot interactively →