BMP7

Across TCGA cell cohorts, BMP7 mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible BMP7-associated genes across cancer lineages are DCD, SIGLEC7, and ZNF716. Each is linked with BMP7 in more than 1 cancer types. Because this analysis shows association rather than direction, both BMP7-to-partner and partner-to-BMP7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DCD grouped by BMP7-low versus BMP7-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BMP7→partner) and Y-score (partner→BMP7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	DCD →	+0.068	+4.977	.001	.007	3	1
LUNG_NSCLC_LUAD	SIGLEC7 →	+0.049	+4.536	<.001	<.001	3	1
LUNG_NSCLC_LUAD	ZNF716 →	+0.343	+3.882	.008	.003	3	1
LUNG_NSCLC_LUAD	MS4A13 →	+0.169	+4.228	<.001	<.001	3	1
LUNG_NSCLC_LUAD	OR4M2 →	+0.138	+3.887	<.001	.002	3	1
BLOOD_Lymphoma	REG3G →	+0.044	+4.867	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

DCD by BMP7 expression — SKIN

Explore this box plot interactively →