BMP6

Across TCGA cell cohorts, BMP6 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,257 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible BMP6-associated GO terms across cancer lineages are Transcription initiation at RNA polymerase II promoter, Positive regulation of steroid hormone biosynthetic process, and Nuclear-transcribed mRNA catabolic process. Each is linked with BMP6 in more than 8 cancer types. Because this analysis shows association rather than direction, both BMP6-to-partner and partner-to-BMP6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Transcription initiation at RNA polymerase II promoter grouped by BMP6-low versus BMP6-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (BMP6→partner) and Y-score (partner→BMP6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Transcription initiation at RNA polymerase II promoter →	+0.092	+1.602	<.001	<.001	3	9
STOMACH	Positive regulation of steroid hormone biosynthetic process →	-0.409	-1.168	<.001	<.001	3	9
LIVER	Nuclear-transcribed mRNA catabolic process →	+0.068	+2.515	<.001	.004	3	8
URINARY_TRACT	Cellular response to iron ion →	-0.092	-1.543	.002	.001	3	8
STOMACH	Microtubule bundle formation →	-0.053	-1.186	.001	.002	3	8
LIVER	Nucleic acid catabolic process →	+0.051	+2.557	.002	.005	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,257 associations by consensus.

Transcription initiation at RNA polymerase II promoter by BMP6 expression — OESOPHAGUS

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